Diabetes Mellitus is a group of metabolic disorder that results in hyperglycemia due to decrease insulin production or inefficient insulin utilization. Based on World Health Organization (WHO) recommendation, diabetes mellitus is classified into three major subtypes: type 1 (insulin dependent diabetes mellitus), type 2 (non-insulin dependent diabetes mellitus NIDDM) and gestational diabetes (diabetes that develop when a woman is pregnant). Diabetes as a metabolic disorder have several marketed medications to alleviate its symptoms. However, this over the counter drugs/antidiabetics are expensive with its associated side effects. Medicinal plants are gaining importance in the management of Diabetes Mellitus as they are cost effective and also displays improved therapeutic effects with lesser side effects. The use of Irvingia grandifolia has been found to be efficacious in the management of the disease but the effect of this herb on plasma urea, creatinine concentrations and white blood cell count has not been characterized so far. The effect was investigated and found out that there is no pronounced effect of the herb on plasma creatinine concentration based on student distribution (t-test). Also, there is no significant effect on plasma urea concentration, white blood cell count (total and differential) also found from student distribution (t-test) after comparing treated animals with control animals.

Key words: Diabetes Mellitus, Antidiabetics, Medicinal Plants, Hyperglycemia,  Hypoglycemia, Plasma urea, Plasma Creatinine, White cell count.