This study aimed at evaluating some metabolite characteristics of the growing pig brain, morphometry and response to the dietary composition of Spondiasmombin leaf meal (SMLM).Twelve (12) growing male pigs weighing 13kg were randomly allotted to four treatment-supplemented maize feed ingredients with T1 to T4: 0, 5, 6 and 7% with Spondiasmombin leaf meal (SMLM) w/w in a completely randomized design with three animals per treatment and one animal in each replicate. Glucose and total protein concentrations in both blood and brain were assessed as well as morphometry of different brain regions; cerebrum alongside hemispheric difference, cerebellum, hypothalamus, pons, hippocampus, amygdala and pituitary. Results show that r² of 0.46 shows that 46% of the weight observed is due to the feed offered and means of glucose concentration in the brain significantly differ among treatments with T4 as the highest. also, higher blood-brain protein concentrations in T2 and T4were similar but significantly different from others. The same level of protein in blood and brain was observed in T3 which indicates little is available for tissue formation and weight gain. This study shows that SMLM inclusion in diets of up to 7%, increase in crude protein and development of different brain regions were observed in glucose and total protein concentration in the brain of animals.

Keywords: Nutrition, response, Spondias Mombin Leaf Meal, brain, gluconeogenetic, protein