Advanced Journal of Surgical Pathology (AJSP) ISSN 7853-1292,  Vol. 2(1), pp. 007-016, June, 2025. © Advanced Scholars Journals

Review Paper

Hypersplenisism caused by Portal hypertension due to abnormal liver function

¹Ahmad Mahmood , ²Mohammad Shoaib, ³Mustafa Zhayier , ⁴Rexiati Ruze *⁵Tiemin Jiang

Department of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital, Xinjiang Medical University, No. 137 Liyushan South Road, 830011 Urumqi, China.

*Corresponding Author’s Email Address: [email protected]

Accepted 13^th April, 2024.

Abstract 

 Portal hypertension refers to a range of complications that arise from elevated pressure in the portal vein system, which can be caused by various factors. The primary causes of portal hypertension are cirrhosis induced by viral hepatitis and non-cirrhotic factors such as Budd-Chiari syndrome, portal cavernous transformation, and regional portal hypertension. Patients with portal hypertension experience increased blood flow and resistance in the portal vein, leading to enlargement of the spleen and increased splenic function. This, in turn, can result in a decrease in blood cells and an overgrowth of bone marrow hematopoietic cells, leading to complications like anemia, bleeding, and infection. The treatment for splenomegaly induced by portal hypertension involves both medical and surgical approaches, with surgical treatment being the primary method. This article provides an overview of the common treatment options for splenomegaly caused by portal hypertension.